What Changed in the USANA Essentials/CellSentials Formula?

Nearly two-thirds of the ingredients in the CellSentials have had some modification to either the dose or form compared to what was used in the Essentials. These changes vary by market, some of the key differences are:

The Essentials provided beta-carotene as the only source of vitamin A activity. The CellSentials deliver a combination of beta-carotene, retinyl acetate, and mixed carotenoids to provide vitamin A activity.

• Recent research has indicated that some individuals have a limited ability to convert beta-carotene to vitamin A. Excess body weight can also reduce the efficiency of conversion, and there are genetic polymorphisms that decrease the ability to convert beta-carotene to vitamin A. Individuals may have different abilities to convert provitamin A carotenoids to vitamin A. These differences in conversion efficiency may be due to the genetic variability in beta-carotene metabolism of individuals. Consequently, provitamin A carotenoids alone may not be a good vitamin A source for those individuals of the poor converter phenotype.

• A combination of multiple sources of vitamin A activity ensures that the CellSentials provide an advanced dose of vitamin A to everyone, regardless of genetic differences.

The Essentials provided vitamin E primarily as alpha-tocopherol. The CellSentials provide a more balanced approach to vitamin E activity with a lower dose of alpha-tocopherol and a much greater dose of mixed tocopherols (gamma, delta, and beta-tocopherols), all of which supply vitamin E activity.

• In addition to their vitamin E activity, mixed tocopherols also serve as antioxidants and have a variety of biological activities that alpha-tocopherol alone cannot provide. Providing a broad range of tocopherols offers a valuable addition the health-supporting nutrients included in the new CellSentials.

The CellSentials have a much larger dose of vitamin K than the Essentials. The CellSentials also have the addition of vitamin K2.

• Vitamin K is an essential nutrient required for the normal biosynthesis and activation of several key proteins. It influences the level of osteocalcin in bone-forming cells, and may play a role in preventing postmenopausal osteoporosis.

• Vitamin K2, also called menaquinone, is produced by bacteria, including some found in the human intestinal tract. Research has shown that supplementing additional vitamin K2 may provide additional bone and cardiovascular health benefits.

The CellSentials have much greater dose of iodine than the Essentials.

• Iodine is crucial for the production of thyroid hormones. Dietary surveys have shown that many people are becoming increasingly deficient in this important mineral, especially those limiting their salt intake.

The CellSentials InCelligence complex has a much greater dose of Meriva curcumin, green tea extract, quercetin, hesperidin, and N-acetyl L-cysteine.

• The individual components of the InCelligence complex each have unique health benefits and antioxidant protection. As a whole though, these phytochemicals can influence endogenous antioxidant production and cell signaling pathways to help promote healthy cell lifecycles.

The CellSentials have an increased dose of alpha-lipoic acid, and resveratrol was added to the complex . The previous AO booster contained both alpha-lipoic acid and resveratrol. These ingredients are now included in the CellSentials InCelligence complex, in doses greater that were found in the separate AO booster.

• Alpha-lipoic acid is a vitamin-like antioxidant that is both fat and water-soluble and has the ability to regenerate other antioxidants back to active states.

• Resveratrol is a polyphenol found naturally in the skin of grapes, blueberries, raspberries, and mulberries. It is an antioxidant that may play an important role in supporting cardiovascular health. It is also an important part of the CellSentials InCelligence complex, as research shows that it may have an impact on endogenous antioxidant production and cell signaling pathways to help promote healthy cell lifecycles.

In some markets folic acid was decreased in the CellSentials, in comparison to the Essentials.

• USANA has always provided an advanced dosage of folic acid to ensure protection against neural tube defects. However, food fortification of folic acid has increased dietary intakes significantly. The folic acid dosage was lowered to a significant, but more moderate level to account for the increased dietary intake and to make room for increases in other important nutrients.

The CellSentials contain over double the Choline of the Essentials.

• Average choline intakes for men, women, older children, and during pregnancy are far below the Adequate Intake established by the Institute of Medicine. Choline is necessary for neurotransmitter synthesis (acetylcholine), cell-membrane signaling (phospholipids), lipid transport (lipoproteins), and methyl-group metabolism (homocysteine reduction). It is the major dietary source of methyl groups via the synthesis of S-adenosylmethionine.

The CellSentials Core Minerals contains Calcium Ascorbate and Magnesium Ascorbate, two good bioavailable sources of these minerals. The use of Calcium Ascorbate and Magnesium ascorbate also moved much of the vitamin C from the Mega Antioxidant to the Mineral.  As such it has multiple benefits.  It provides both minerals and vitamin C in one tablet, in highly bioavailable forms, and it gave us more room in the Vita Antioxidant tablet to add some very important nutrients (such as the InCelligence Complex, increased choline, mixed carotenoids, additional mixed tocopherols, and additional vitamin K).

SOURCE: USANA Health Sciences